Wednesday, September 18, 2013

Egg retrieval / follicle aspiration

The day our baby was conceived. I still didn't finish that book.

While we were going through IVF I desperately wanted to read how the process was for other couples. I wondered about the specifics, the practical, the physical. So, for what it's worth, here goes my experience. After the ovarian stimulation period* (FSH / [Gonal or Fostimon] from days 3 to 10) and several blood tests (AMH, estradiol) to check everything was fine, and after closely looking at my follicles grow during those days, I had the trigger shot  (hCG / [Pregnyl]) that would stimulate ovulation together with another injection (Ganirelix/ GnRH [Orgalutran]) that would actually prevent me from ovulating too early. Two days after the trigger shot (actually 34 hours later) I was scheduled at the hospital for the egg retrieval.

I could choose between Dormicum (Midazolam) and a painkiller, which would have had me sleep through the whole thing or Pethidine, a very strong painkiller. I had the latter, because they told me I could then stay alert and see what was happening. The egg retrieval is done with a long, hollow needle that "sucks" each follicle, the needle is guided transvaginally with the help of ultrasounds / echography. Mark liked this part he said it was fun to watch, like a videogame (Call of Duty?), aiming and taking the follicles, who would turn from being black bubbles, to empty little dots. On one of my ovaries it did not really hurt: each time they took a follicle it felt like a small "kick" or "punch" and then it was done, it lasted just one second, and on to the next follicle. On the other ovary (I think because it was higher and more to the back) it was a bit more painful, each aspiration felt like being kicked in the stomach, but it was not super awful either. On that same day Mark had to give a sample, the lab analysed the eggs and they proceed with IVF or ICSI (intracellular sperm injection). They do the latter when the sperm volume is low.

Right after the aspiration I felt a bit dizzy (not during the procedure), I think as soon as it was over my pressure went down. We stayed in observation for an hour or so, until I felt better, and then we were allowed to leave. Those days I had to drink 2 liters of water per day and check my temperature and weight every day.

A day after the procedure we were informed that out of the 19 follicles that were retrieved (they take all of them, regardless of the maturation state (size) even if some were not fully grown), 13 eggs were mature and we had 7 fertilizations. 3 days after the aspiration, the embryo transfer took place, which was quite simple (similar to getting a PAP smear, except we were watching everything on the ultrasound screen). They only transferred 1 embryo, to avoid multiple pregnancies, the rest of the embryos would have been frozen, but we were informed a few days later (in the middle of the 2 week wait, to add to the stress) that none of them continued their development further, so we don't have any frozen embryos. For the two weeks after the egg retrieval I had to take progesterone (to support the endometrium / mucus layer). Depending on how many follicles they get some people get an hCG shot instead of the progesterone.

So that was that... 13 days after the transfer we got the happy news. We feel so incredibly blessed. My heart and hope and wishes are with everyone who is going through this. 
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*The aim of the stimulation is to make your ovaries produce as many eggs as possible (superovulation). In my case I was stimulated with  225 IU FSH per day: 150 in the morning and 75 at night). These are subcutaneous shots (in the belly) and are less painful than they sound, the needle is very small (same as for insulin). It was Mark who injected me every single time. I am able to inject all kinds of animals but could not muster the courage to inject myself. It was also nice to have him do it, and he loved playing doctor. I did not really feel any of the side effects I half dreaded, except maybe some bloatedness. The follicle growth is monitored with ultrasound (the famous transvaginal wand, ugh). I think I had to go on days 3, 7, 9 and 11. Once the follicles reached a certain size (around 20 mm) they injected the hCG (Pregnyl), which "triggers" the ovulation.
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Post edit The boy read this and said it might be useful to clarify what all the acronyms are, so:

FSH: Follicle-Stimulatin Hormone, also known as follitotropin. (Commercial names: Gonal, Fostimon and others).As the name says, it is used to stimulate the growth of follicles, the little "bags of fluid" in which eggs mature / develop.

AMH: Anti müllerian hormone. It is used to test "ovarian reserve" (to give an idea of how many eggs are left in the ovaries) and  "to rationalise the programme of ovulation induction and decisions about the number of embryos to transfer in assisted reproduction techniques to maximise pregnancy success rates whilst minimising the risk of ovarian hyperstimulation syndrome (OHSS)".

hCG: Human chorionic gonadotropin. It is in this case used to simulate the peak of LH (luteinizing hormone) that precedes ovulation. Also called "trigger shot" because it stimulates ovulation (34-36 hours after the injection).

GnRH: Gonadotropin Releasing Hormone. This is the boss of the hormonal axis that controls reproduction, as it starts the whole process. If given at certain times and concentrations it can actually act as negative feedback, blocking certain processes. In this case it is used to prevent early ovulation. 
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The blog, Fertility chronicles   presents several articles explaining the causes of infertility, the different tests available and how they are interpreted, and different factors that can affect the outcomes of IVF. (I am linking to them because I think the information given in their articles is simple and easy to understand. They have developed a model to predict your chances at success with IVF based on your tests results however this is not a sponsored link.)

19 comments:

  1. I really am so happy for you that it all worked for you :-) xox

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    1. Thanks so much... we almost could not believe it, and we are so immensely grateful. It feels surreal.

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  2. Me encanta la historia tan real, biológica y a la vez cariñosa :)

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  3. I am so happy for you, what luck that they chose the one embryo who was strong enough to create a baby! I think it was meant to be :)xo

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    1. Thanks ! I think so too, it is such a huge blessing, I don't want to take it for granted for 1 second.

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  4. Thanks for sharing this. I know some parts of this journey must have been very tough for you and Mark. Looking forward to hearing any pregnancy updates you feel like sharing. I hope you're able to enjoy it thoroughly.

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    1. Thanks. These last few weeks we have really been enjoying, as the riskiest period passed, and as we settle in this new reality. Those first weeks I was still worrying about this and that, slowly I have been letting go and we have been appreciating everything.

      This journey was tough for sure, there were moments where I wasn't sure if I could go on, and there is so much uncertainty, so much that feels like an indefinite, uncontrollable pause...

      I will for sure post pregnancy updates every now and then... for now it is not very exciting (symptom wise) as my clothes mostly still fit (though I look like I am "growing" / getting thicker) and I mostly feel tired some days, though my energy seems to be coming back.

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  5. UUUUUUUGH the ultrasound wand. I swear when someone invents something more comfortable, I will campaign to create a holiday honoring that person. Or something. And am I the only person that can't look the tech in the eye until that thing is out? (and why is it called a wand anyway? There is nothing magical about that experience. ugh) Major props to you for going through with everything. But wait until you start feeling kicks and squirms (and hiccups!). That's when reality hits that there really is a mini person in your growing belly :)

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    1. I like to refer to that ultrasound wand as dildo cam ...

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    2. That ultrasound wand is awful... I think someone (Sadie @Invincible Spring?) started calling it transvaginal invader and I think it fits.

      I can't wait to start feeling kicks and movement... supposedly anytime soon (but it will feel like bubbles or butterflies?). I have been paying attention and sometimes I feel something but I can't tell if it's gas or my bowels moving around or little one.

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  6. Thank you for sharing the whole process. Medical interventions in conception always seem so surrounded in mystery - I know they're doable, and I know they are stressful for a lot of people, but I'd never actually heard anything about what the experience is like before.

    And I am so so happy for you that this has worked.

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    1. Thanks so much:) I decided to share because of what you say... the technical information is there, but real experiences are not so easy to find. Or you find horror stories. For us it was the emotional rollercoaster that was the hardest... as for the physical at some point either you are trained or you just go with it, and it really is not all that painful (just maybe weird). I guess also black humor / laughing about it / not thinking too much help as well.

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  7. Oh I can't believe that you opted to be awake for the egg retrieval! I went under a general so was asleep for the whole thing - I'm too squeamish and didn't want to watch them stick a giant needle in my vagina hahaha

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    1. I definitely wanted to watch it all, but I managed NOT to look at the giant needle, I just looked at the screen. I was actually curious about it and wanted to see it at the end, but I was kind of dizzy / drowsy and I was put in a cot to move rooms so I did not see it. On the screen it looked like a long green line (light saber maybe?).

      I am thinking of you, I lit a candle for you yesterday, I hope it is all going well.

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  8. And again contrast, had a little tear in my eye reading this. Being extremely sentimental has always been a character flaw. Congratulations again :D

    xx

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  9. Thank you for sharing Amanda! I think this will be so helpful as I prepare for our IVF cycle...I know the basics from blogging as long as I have, but no one else seems to write in this specific detail! I also think that the protocols here in the UK are very similar to NL (side note: I know that the single embryo transfer is to reduce risks associated with multiples, but honestly? I'd love to think I could get two out of it and finally get the family I've always wanted...alas, our clinic has the same policy as yours) This is a great resource!

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    1. I am glad you appreciate it, I thought I would put it out there since it's also the kind of information I could not seem to find.

      I would also have liked to have more than 1 embryo transferred, but they wouldn't do it. The clinics are actually strictly monitored / regulated by the government (though I don't think it would be that difficult to sneak a 2nd embryo in). Anyhow, of course it has to do with reducing the risks associated with multiples, but, since it is a social system, I think it also has to do with the fact that multiple pregnancies need more care / present more costs... at least here you get all your checkups done by the gynaecologists as well as birth, whereas the rest get sent to midwife care (it's not even a choice, except for the birth itself where you can choose to do so at the hospital, at home or at birth centers).

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